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Means ± SEM plasma glucose, C-peptide, insulin, and epinephrine concentrations before and after ingestion of the sulfonylurea glimepiride in basal insulin–infused patients with type 1 diabetes (T1DM) (●) and nondiabetic (ND) individuals (○), the latter infused with glucose intravenously to prevent hypoglycemia. Differences in insulin, C-peptide, and insulin levels, P < 0.0001.
