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Means ± SEM plasma glucagon concentrations (left panels) and change in plasma glucagon from zero time (right panels) before and after ingestion of a mixed meal (top panels) and of the sulfonylurea glimepiride (bottom panels) in basal insulin–infused patients with type 1 diabetes (T1DM) (●) and nondiabetic (ND) individuals (○). Differences in baseline-adjusted glucagon levels, P < 0.0001.
