Table II.
Inflammation measurements in the intestine of mice with Apc1638 and Mlh1 mutations
| Inflammation scoresa |
|||
| Degree | Depth | Severity | |
| Apc1638N/+ mice | |||
| AIN-76A | |||
| Duodenum | 1.32 ± 0.27 | 1.21 ± 0.26 | 2.68 ± 0.78 |
| Cecum | 0.29 ± 0.16 | 0.21 ± 0.11 | 0.29 ± 0.16 |
| Proximal colon | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Distal colon | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Sulindac | |||
| Duodenum | 0.00 ± 0.001 | 0.00 ± 0.001 | 0.00 ± 0.001 |
| Cecum | 2.42 ± 0.291 | 2.25 ± 0.281 | 6.00 ± 0.911 |
| Proximal colon | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Distal colon | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Mlh1+/− mice | |||
| AIN-76A | |||
| Duodenum | 0.00 ± 0.00* | 0.00 ± 0.00* | 0.00 ± 0.00* |
| Cecum | 0.33 ± 0.17 | 0.33 ± 0.17 | 0.33 ± 0.17 |
| Proximal colon | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Distal colon | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Sulindac | |||
| Duodenum | 1.18 ± 0.321* | 1.23 ± 0.341* | 3.64 ± 1.261* |
| Cecum | 2.18 ± 0.241 | 1.82 ± 0.181 | 4.73 ± 0.601 |
| Proximal colon | 0.09 ± 0.09 | 0.09 ± 0.09 | 0.18 ± 0.18 |
| Distal colon | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
Mean ± SEM.
a
Inflammatory scores included degree of inflammatory cells, depth of inflammatory cell infiltration and inflammatory severity (degree × depth). By Mann–Whitney test and binomial exact calculation compared with corresponding AIN-76A: 1P < 0.001; compared with corresponding diet group of Apc1638N/+ mice: *P < 0.001.