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. 2009 Sep 23;30(11):1932–1940. doi: 10.1093/carcin/bgp216

Fig. 3.

Fig. 3.

Delphinidin inhibits MAPKK4 or PI-3K activity in vitro and ex vivo. (A and C) MAPKK4 (A) and PI-3K (C) activity assays were performed as described in Materials and Methods. (B and D) Delphinidin inhibits UVB-induced MAPKK4 or PI-3K activity. JB6 P+ cells were treated with delphinidin at the concentrations indicated (0, 10 or 20 μM) for 1 h before being exposed to 0.5 kJ/m2 UVB and harvested after 15 min. MAPKK4 (B) or PI-3K (D) activity was measured as described in Materials and Methods. For (A and B) data are shown as means ± SDs and asterisks indicate significant inhibition of MAPKK4 activity by delphinidin compared with the active MAPKK4 only group (A) or the group treated with UVB (B) alone (**P < 0.01).