Table I.
Characteristics of study subjects and their association with HCC
| Characteristic | Healthy controls (N = 404) | Non-HCC subjects with HBV infection (N = 482) | HCC patients with HBV infection (N = 202) | P value | ||
| ASC (n = 280) | CHB (n = 110) | LC (n = 92) | ||||
| Sex (male) | 318 (78.7) | 160 (57.1) | 87 (79.1) | 72 (78.3) | 159 (78.7) | 0.001a |
| Age (year) | 52.0 ± 9.61 | 43.7 ± 7.94 | 50.1 ± 12.28 | 50.5 ± 8.46 | 52.9 ± 9.76 | 0.000a |
| Genotype | ||||||
| B | ND | 87 (31.1) | 22 (21.8) | 15 (17.9) | 11 (5.8) | 0.000b |
| C | ND | 180 (64.3) | 79 (78.2) | 69 (82.1) | 175 (91.6) | <0.01c |
| Others | ND | 13 (4.6) | ND | ND | 5 (2.6) | |
| HBeAg | ||||||
| Positive | ND | 129 (46.1) | 40 (36.4) | 40 (43.5) | 48 (23.8) | 0.018d |
| Negative | ND | 151 (53.9) | 70 (63.6) | 52 (56.5) | 154 (76.2) | 0.000e |
| HBV DNA (Log10 copies/ml) | ND | ND | 4.70 ± 1.67 | 4.17 ± 1.35 | 3.92 ± 1.17 | 0.000f |
| ALT (Log10 U/l) | ND | ND | 2.09 ± 0.48 | 1.85 ± 0.49 | 1.69 ± 0.31 | <0.01c |
Data shown as N (%), except age, ALT and HBV DNA; ND, no data.
a
Between ASC and HCC.
b
Between ASC and HCC.
c
Between HCC and CHB and between HCC and LC.
d
Between CHB and HCC.
e
Between HCC and ASC and between HCC and LC.
f
Between CHB and HCC.