Table II.
The frequencies of the polymorphisms at NFKB1 −94 and NFKBIA 3′-UTR, −519, −826 or −881 in the participants
| Polymorphisms (accession code) | Alleles | Healthy controlsa | Non-HCC with HBV infectiona | HCC with HBV infectiona | AOR1 (95% CI) | OR2 (95% CI) | AOR2 (95% CI) |
| NFKB1 −94 (rs28720239, ATTG1 > ATTG2) | ATTG1/ATTG1 | 124 (30.7) | 111 (24.1) | 35 (17.3) | 1.00 | 1.00 | |
| ATTG1/ATTG2 | 183 (45.3) | 192 (41.7) | 84 (41.6) | 1.60 (1.01–2.53) | 1.39 (0.88–2.19) | 1.30 (0.80–2.10) | |
| ATTG2/ATTG2 | 97 (24.0) | 157 (34.1) | 83 (41.1) | 3.01 (1.87–4.85) | 1.68 (1.05–2.67) | 1.62 (1.00–2.64) | |
| ATTG2 (ATTG1/ATTG2+ATTG2/ATTG2) | 280 (69.3) | 349 (75.8) | 167 (82.7) | 2.09 (1.37–3.19) | 1.52 (0.99–2.32) | 1.44 (0.93–2.25) | |
| HWE P valueb | 0.07 | 0.00 | |||||
| NFKBIA 3′-UTR (rs57898959, A>G) | AA | 138 (34.2) | 186 (38.6) | 70 (34.7) | 1.00 | 1.00 | 1.00 |
| AG | 185 (45.8) | 193 (40.0) | 67 (33.2) | 0.71 (0.47–1.06) | 0.92 (0.62–1.36) | 1.01 (0.67–1.53) | |
| GG | 81 (20.0) | 103 (21.4) | 55 (32.2) | 1.61 (1.04–2.50) | 1.68 (1.11–2.54) | 1.49 (0.96–2.31) | |
| G (AG+GG) | 266 (65.8) | 296 (61.4) | 122 (65.4) | 0.98 (0.68–1.39) | 1.19 (0.84–1.67) | 1.19 (0.83–1.71) | |
| HWE P valueb | 0.19 | 0.00 | |||||
| NFKBIA −519 (rs2233408, C>T) | CC | 321 (79.5) | 368 (77.8) | 162 (80.2) | 1.00 | 1.00 | 1.00 |
| CT | 74 (18.3) | 95 (20.1) | 31 (15.3) | 0.84 (0.53–1.33) | 0.74 (0.48–1.16) | 0.80 (0.50–1.28) | |
| TT | 9 (2.2) | 10 (2.1) | 9 (4.5) | 1.98 (0.77–5.09) | 2.04 (0.82–5.13) | 1.64 (0.62–4.34) | |
| T (CT+ TT) | 83 (20.5) | 105 (22.2) | 40 (19.8) | 0.96 (0.63–1.47) | 0.87 (0.58–1.30) | 0.89 (0.58–1.38) | |
| HWE P valueb | 0.06 | 0.19 | |||||
| NFKBIA −826 (rs2233406, C>T) | CC | 291 (72.0) | 394 (81.7) | 149 (73.8) | 1.00 | 1.00 | 1.00 |
| CT | 105 (26.0) | 76 (15.8) | 52 (25.7) | 0.98 (0.66–1.44) | 1.81 (1.21–2.70) | 1.89 (1.24–2.89) | |
| TT | 8 (2.0) | 12 (2.5) | 1 (0.5) | 0.25 (0.03–2.00) | 0.22 (0.03–1.71) | 0.25 (0.03–2.01) | |
| T (CT+ TT) | 113 (28.0) | 88 (18.3) | 53 (26.2) | 0.92 (0.63–1.35) | 1.59 (1.08–2.35) | 1.67 (1.11–2.53) | |
| HWE P valueb | 0.68 | 0.00 | |||||
| NFKBIA −881 (rs3138053, A>G) | AA | 331 (81.9) | 449 (93.2) | 164 (81.2) | 1.00 | 1.00 | 1.00 |
| AG | 73 (18.1) | 33 (6.8) | 38 (18.8) | 1.06 (0.69–1.64) | 3.15 (1.91–5.20) | 3.32 (1.95–5.65) | |
| GG | 0 | 0 | 0 | ND | ND | ND | |
| HWE P valueb | 0.06 | 1.00 |
AOR, odds ratio adjusted by age and sex; AOR1: healthy controls versus HCC with HBV infection; OR2 and AOR2: non-HCC with HBV infection versus HCC with HBV infection; HWE, Hardy–Weinberg equilibrium; ND, no data.
a
Data were presented as n (%).
b
Significance probability determined by HWE test.