Table III.
Association of the polymorphisms with the development of HCC in different HBV genotype groups
| Polymorphism | HBV genotype B | HBV genotype C | ||||
| Non-HCCa | HCCa | AOR (95% CI) | Non-HCCa | HCCa | AOR (95% CI) | |
| NFKB1 −94 | ||||||
| ATTG1/ATTG1 | 29 (24.8) | 3 (27.3) | 1.00 | 78 (24.8) | 32 (18.3) | 1.00 |
| ATTG2 (ATTG1/ATTG2+ATTG2/ATTG2) | 88 (75.2) | 8 (72.7) | 0.747 (0.18–3.11) | 236 (75.2) | 143 (81.7) | 1.46 (0.90–2.37) |
| NFKBIA 3′-UTR | ||||||
| AA | 51 (41.1) | 3 (27.3) | 1.00 | 123 (37.5) | 60 (34.3) | 1.00 |
| G (AG+GG) | 73 (59.8) | 8 (72.7) | 2.05 (0.50–8.37) | 205 (62.5) | 115 (65.7) | 1.13 (0.76–1.70) |
| NFKBIA −519 | ||||||
| CC | 101 (82.8) | 11 (100.0) | 1.00 | 250 (77.9) | 142 (81.1) | 1.00 |
| T (CT+TT) | 21 (17.2) | 0 | ND | 71 (22.1) | 33 (18.9) | 0.87 (0.53–1.42) |
| NFKBIA −826 | ||||||
| CC | 104 (83.9) | 9 (81.8) | 1.00 | 267 (81.4) | 129 (73.7) | 1.00 |
| T (CT+TT) | 20 (16.1) | 2 (18.2) | 1.13 (0.22–5.74) | 61 (18.6) | 46 (26.3) | 1.71 (1.07–2.73)b |
| NFKBIA −881 | ||||||
| AA | 115 (92.7) | 10 (90.9) | 1.00 | 308 (93.9) | 142 (81.1) | 1.00 |
| AG | 9 (7.3) | 1 (9.1) | 1.15 (0.13–10.41) | 20 (6.1) | 33 (18.9) | 4.02 (2.14–7.59)c |
AOR, odd ratio adjusted by age and sex; ND, no data.
a
Data were presented as n (%).
b
P = 0.024.
c
P = 0.000.