Table V.
Multivariate regression analysis for factors independently associated with the risk of HCC
| Variable | HCC versus healthy controls |
HCC versus ASC |
HCC versus (CHB+LC) |
|||
| AOR (95% CI) | P | AOR (95% CI) | P | AOR (95% CI) | P | |
| Age | NS | 1.12 (1.09–1.15) | 0.000 | NS | ||
| Sex | ||||||
| Female | 1.00 | |||||
| Male | NS | 3.86 (2.23–6.69) | 0.000 | NS | ||
| NFKB1 −94 | ||||||
| ATTG1/ATTG1 | 1.00 | 1.00 | ||||
| ATTG2 (ATTG1/ATTG2+ ATTG2/ATTG2) | 2.11 (1.39–3.22) | 0.000 | NS | 1.84 (1.05–3.24) | 0.034 | |
| NFKBIA −519 | ||||||
| CC | 1.00 | |||||
| T (CT+TT) | NS | 0.52 (0.28–0.96) | 0.038 | NS | ||
| NFKBIA −826 | ||||||
| CC | 1.00 | |||||
| T (CT+TT) | NS | 2.74 (1.48–5.08) | 0.001 | NS | ||
| NFKBIA −881 | ||||||
| AA | 1.00 | |||||
| AG | NS | NS | 3.53 (1.54–8.08) | 0.003 | ||
| HBV genotype | ||||||
| B | ND | 1.00 | 1.00 | |||
| C | ND | ND | 10.43 (4.75–22.88) | 0.000 | 4.01 (1.80–8.92) | 0.001 |
| HBeAg | ||||||
| Negative | ND | 1.00 | 1.00 | |||
| Positive | ND | ND | 0.39 (0.23–0.65) | 0.000 | 0.50 (0.30–0.85) | 0.010 |
| ALT (Log10 U/l) | ND | ND | ND | 0.18 (0.10–0.33) | 0.000 | |
ND, no data; NS, no statistical significance.