Table 1.
Tools for manipulating neuronal excitability in Drosophila.
| Type | Tool | Action | Reference |
|---|---|---|---|
| Constitutive suppressors | Tetanus Toxin Light Chain (TNT) | Synaptic Block | Sweeney et al., 1995 |
| Inward Rectifier (Kir2.1) | ↓ Excitability | Baines et al., 2001 | |
| Two-pored “leak” Channel (dORK) | ↓ Excitability | Nitabach et al., 2002 | |
| Voltage-gated K+ Channels (EKO, Shaw) | ↓ Excitability | Hodge et al., 2005; White et al., 2001b | |
| Conditional suppressor | Dynamin Mutant (UAS-Shits1) | Synaptic Block | Kitamoto, 2001 |
| Constitutive activator | Bacterial Na+ Channel (NaChBac) | ↑Excitability | Luan et al., 2006a; Nitabach et al., 2006 |
| Tethered Toxin (δ-ACTX-Hv1a) | ↑Excitability | Wu et al., 2008 | |
| Conditional activators | Thermosensitive TRPs (TRPM8, dTrpA1) | Depolarize | Hamada et al., 2008; Peabody et al., 2009 |
| ChR2 | Depolarize | Schroll et al., 2006 | |
| Light Uncaged ATP (P2X2) | Depolarize | Lima and Miesenbock, 2005 |