Table 2.
Genotypes distribution of 8q24 polymorphisms and odds ratios for the minor alleles and genotypes.
| Allelic model | Genotype model | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Model 1 *1 | Model 2 *2 | Heterozygote | Minor homozygote | |||||||||||||
| 8q24 locus | Genotype | OR | 95% CI | p-value | ORa | 95% CI | p-value | ORa | 95% CI | p-value | ORa | 95% CI | p-value | |||
| rs6983267 (Minor allele: G, MAF*1 in controls = 0.338) | ||||||||||||||||
| TT | TG | GG | UK*4 | |||||||||||||
| case/control | 181/418 | 222/436 | 73/107 | 3/1 | 1.22 | 1.04-1.44 | 0.0144 | 1.25 | 1.06-1.48 | 0.0071 | 1.19 | 0.93-1.52 | 0.1665 | 1.64 | 1.15-2.35 | 0.0063 |
| rs10090154 (Minor allele: T, MAF in controls = 0.153) | ||||||||||||||||
| CC | CT | TT | UK | |||||||||||||
| case/control | 355/689 | 112/247 | 11/23 | 3/3 | 0.90 | 0.72-1.12 | 0.3443 | 0.87 | 0.69-1.09 | 0.2140 | 0.83 | 0.63-1.08 | 0.1690 | 0.90 | 0.43-1.89 | 0.7854 |
*1 Crude conditional logistic regression model.
*2 Adjusted for age as continuous variable, drinking (non, low, moderate, heavy, and unknown), smoking (non, moderate, heavy, unknwon), BMI (< 22.5, < 25, < 27.5, 27.5-, unknown), folate in tertile (T1, T2, T3, and unknown), total energy intake, family history of colorectal cancer, average recreational exercise (none, < 0.5 hour/day, 0.5-hour/day) in conditional logisitic regression.
*3 MAF indicates minor allele frequency.
*4 UK indicates the subjects whose genotyping was unsuccessful.