Table 4.
Review of results of 8q24 rs6983267 for colorectal cancer in allelic model.
| Author | Year | Case/Control | Country | Study subjects | Per allele OR (95%CI) | Adjustment |
|---|---|---|---|---|---|---|
| Haiman et al. | 2007 | 1,807/5,511 | USA | Pooled | 1.25 (1.12-1.38) | Sex |
| 217/1,049 | African American | 1.37 (0.98-1.91) | Sex | |||
| 381/1,197 | Japanese American | 1.13 (0.96-1.34) | Sex | |||
| 61/347 | Native Hawaiian | 1.59 (1.02-2.47) | Sex | |||
| 251/1,007 | Latinos | 1.26 (1.02-1.55) | Sex | |||
| 214/973 | European Americans | 1.28 (1.03-1.58) | Sex | |||
| Tomlinson et al. | 2007 | 7,954/6,206 | UK | CRC pooled | 1.21 (1.15-1.27) | Crude |
| 620/960 | Panel A CRC White UK residents | 1.38 (1.19-1.59) | Crude | |||
| 4,361/3,752 | Panel B White UK residents | 1.19 (1.12-1.26) | Crude | |||
| 1,901/1,079 | Panel C | 1.21 (1.09-1.35) | Crude | |||
| 1,072/415 | Panel D European Ancestry | 1.13 (0.96-1.33) | Crude | |||
| 1,425/2,255 | Adenoma pooled | 1.22 (1.10-1.34) | Crude | |||
| 407/1,027 | Panel A Adenoma White UK residents | 1.53 (1.29-1.81) | Crude | |||
| 607/765 | Panel E | 1.05 (0.90-1.23) | Crude | |||
| 411/463 | Panel F | 1.13 (0.93-1.37) | Crude | |||
| Poynter et al. | 2007 | 1,339/2,191 | USA | Population -- based | 1.11 (0.96-1.29) | Age and sex |
| Tuupanen et al. | 2008 | 996/1,012 | Finland | Population-based | 1.22 (1.08-1.38) | Crude |
| Berndt et al. | 2008 | 3,134/4,454 | USA | Colorectal neoplasms pooled | 1.16 (1.07-1.25) | Age, sex, and study |
| 547/1,656 | PLCO | 1.17 (1.01-1.35) | Age and sex | |||
| 1,174/1,293 | PLCO adenoma | 1.24 (1.11-1.39) | Age and sex | |||
| 364/363 | PLCO II | 0.93 (0.75-1.16) | Age and sex | |||
| 544/542 | NHS | 1.10 (0.93-1.30) | Age and sex | |||
| 505/600 | Minnesota | 1.21 (1.01-1.44) | Age and sex | |||
| Ghousaini et al. | 2008 | 2,299/2,284 | UK | Cases from prospective study at East Anglia | 1.27 (1.16-1.37) | Crude |
| Lie et al. | 2008 | 561/721 | USA | Colon cancer cases from SEER Kentucky | 1.69 (1.19-2.40) | Age, sex, BMI, and NSAID use. |
| Cuacasian | 1.61 (1.36-2.30) | Age, sex, BMI, and NSAID use. | ||||
| Schafmayer | 2009 | 2,713/2,718 | Germany | Colorectal cancer cases with German ancestry | 1.22 (1.13-1.31) | Crude |
| Curtin et al. | 2009 | 1,069/1,040 | USA/UK | Colorectal cancer cases from USA/UK | 1.17 (1.03-1.32) | Crude |
| Our study | 481/962 | Japan | HERPACC II participatns (Japanese) | 1.22 (1.04-1.44) | Age and sex | |
| 1.26 (1.06-1.48) | Age, sex, drinking, smoking, BMI, folate consumption, energy, physical exercise, and family history of CRC |