Table 1.
Mixed model of the response to citalopram for HTR1A SNPs and haplotypes.
| SNP | Genotypes | N (frequency) | EMMa | s.e.m. | P value |
|---|---|---|---|---|---|
| rs1364043 b | TT | 902 (0.60) | 10.912 | 0.120 | 0.045 |
| GT | 522 (0.35) | 10.559 | 0.155 | ||
| GG | 78 (0.05) | 10.113 | 0.395 | ||
| rs1423691 b | TT | 409 (0.27) | 10.975 | 0.175 | 0.118 |
| CT | 724 (0.48) | 10.853 | 0.134 | ||
| CC | 369 (0.25) | 10.484 | 0.184 | ||
| rs10042486 b | TT | 370 (0.25) | 10.550 | 0.184 | 0.222 |
| CT | 691 (0.47) | 10.816 | 0.136 | ||
| CC | 406 (0.28) | 10.976 | 0.175 | ||
| Haplotypes | 2N = 3004 | ||||
| A | TCT | 784 (0.26) | |||
| B d | GCT | 676 (0.22) | |||
| C | TTC | 1,532 (0.50) | |||
| D | others | 12 (0.02) | |||
| Combined haplotype | |||||
| 0 | no B haplotype | 906 (0.60) | 11.005 | 0.117 | 0.026 |
| 1 | 1 B haplotype | 521 (0.35) | 10.661 | 0.147 | |
| 2 | 2 B haplotypes | 75 (0.05) | 10.194 | 0.368 | |
| rs6295 c | CC | 45 (0.29) | 8.318 | 0.552 | 0.024 |
| GC | 69 (0.45) | 8.207 | 0.447 | ||
| GG | 39 (0.26) | 10.133 | 0.594 | ||
a
Estimated marginal means over time
b
SN Ps genotyped in extended sample
c
SN P genotyped in exploratory sample
d
haplotype bearing the G allele at rs1364043