Table 2.
Mixed model of the response to citalopram for HTR1BSNPs and haplotypes.
| SNP | Genotypes | N (frequency) | EMMa | s.e.m. | Pvalue |
|---|---|---|---|---|---|
| rs11568817 b | TT | 49 (0.32) | 8.51 | 0.463 | 0.459 |
| TG | 70 (0.46) | 8.41 | 0.393 | ||
| GG | 32 (0.21) | 9.24 | 0.566 | ||
| rs130058b | AA | 77 (0.52) | 8.91 | 0.368 | 0.045 |
| AT | 59 (0.40) | 8.09 | 0.422 | ||
| TT | 11 (0.08) | 10.52 | 0.938 | ||
| rs6296b | GG | 82 (0.54) | 9.39 | 0.352 | 0.01 |
| GC | 60 (0.39) | 7.78 | 0.397 | ||
| CC | 11 (0.07) | 8.46 | 0.904 | ||
| rs6297c | AA | 1296 (0.871) | 10.83 | 0.103 | 0.679 |
| AG | 183 (0.123) | 10.59 | 0.259 | ||
| GG | 9 (0.006) | 10.94 | 1.151 | ||
| rs6298c | CC | 795 (0.54) | 9.58 | 0.148 | 0.022 |
| CT | 558 (0.38) | 9.23 | 0.177 | ||
| TT | 125 (0.08) | 10.32 | 0.372 | ||
| rs1213366c | AA | 463 (0.31) | 11.00 | 0.165 | 0.191 |
| AG | 726 (0.48) | 10.64 | 0.133 | ||
| GG | 312 (0.21) | 10.88 | 0.200 | ||
| Haplotypesb | |||||
| Low | No haplotype 4 | 104 (68.9) | 8.59 | 0.319 | 0.034 |
| Medium | 1 haplotype 4 | 43 (28.5) | 8.29 | 0.485 | |
| High | 2 haplotype 4 | 4 (2.6) | 12.48 | 1.520 | |
a
Estimated QIDS-C marginal means over time
b
SNPs genotyped in exploratory sample. Haplotype 4 from table 4
c
SNPs genotyped in extended sample