Table 3.
Model No | Risk factors adjusted for: | All incident ischaemic heart disease | Fatal ischaemic heart disease | Total mortality |
---|---|---|---|---|
1 | No adjustments | 1.20 (0.87 to 1.64) | 1.76 (1.19 to 2.60)** | 1.56 (1.18 to 2.07)** |
2 | Laboratory batch | 1.13 (0.80 to 1.58) | 1.84 (1.21 to 2.78)** | 1.59 (1.19 to 2.13)** |
3 | Batch, age, smoking, body mass index, total cholesterol concentration, systolic blood pressure, current social class†, father’s social class‡, height, and FEV1§ | 1.07 (0.75 to 1.53) | 1.83 (1.17 to 2.85)** | 1.50 (1.10 to 2.04)* |
4 | Model 2 plus past or prevalent ischaemic heart disease at entry | 1.01 (0.70 to 1.44) | 1.74 (1.11 to 2.73)* | 1.41 (1.03 to 1.93)* |
5 | Model 3 plus plasma viscosity at entry | 0.98 (0.68 to 1.41) | 1.69 (1.06 to 2.68)* | 1.36 (0.99 to 1.87) |
Significance tests for detectable v undetectable IgA antibodies: *P<0.05, **P<0.01.
Trend in risk of total mortality with increasing IgA antibody titre (zero, trace, ⩾1 in 16) was not significant at 5% level in models 3-5.
Trend in risk of fatal ischaemic heart disease with increasing IgA antibody titre was not significant in model 5.
Modelled as six levels: I and II; III non-manual; III manual; IV; V; missing.
Modelled as five levels: I and II; III non-manual; III manual; IV and V; missing or unemployed.
Subjects with missing FEV1 retained in model by use of dummy variable representing missing data.