. Author manuscript; available in PMC: 2010 Nov 1.

Published in final edited form as: Invest Ophthalmol Vis Sci. 2009 Jun 3;50(11):5238–5246. doi: 10.1167/iovs.08-3263

Table 5.

RGC Morphological measurements were correlated with phase retardation per unit depth (PR/UD, proportional to birefringence) for subjects 57205 and 1853. RGC axoplasmic area (A_x) mode, neurotubule number (k) vs. A_x least-squares linear slope (u), and fractional area of axoplasm per unit nerve fiber bundle (f_x) measurements are associated with non-sparse axons only. Axon area (A_a) mode, mitochondrial fractional area (x_m), mitochondria-containing axon profile fraction (m_p), and length of axonal membrane per unit nerve fiber bundle area (L_am/A_b) measurements are associated with both sparse and non-sparse axons (s, ns). Asterisks denote morphological parameters that had a significant correlation with PR/UD. NT, Neurotubules

RGC Axon Morphological Measurement	Abbreviation	57204 OD		1853 OS
RGC Axon Morphological Measurement	Abbreviation	r	P	r	P
Least-Squares Linear Slope (number of NT per unit Ax area), (NT/μm²)	mean u	0.70*	0.0028	0.68	0.0941
Mean RGC Axoplasmic Area Mode (μm²)	mean A_x	0.50*	0.0500	0.81*	0.0145
Mean Axon Area Mode (μm²)	mean A_a	0.47	0.0600	0.79*	0.0184
Neurotubule Density (number of NT per unit RNFL area), (NT/μm²)	mean ρRNFL	0.67*	0.0050	0.61	0.1077
Axoplasmic Fractional Area (per unit RNFL bundle area), %	mean f	0.34	0.1924	0.51	0.1934
Mitochondrial Fractional Area (per unit RNFL bundle area), %	mean x_m	0.02	0.9500	—	—
Mitochondria-Containing Axon Profile Fraction (per unit RNFL bundle area), %	mean m_p	—	—	0.24	0.5708
Axonal Membrane Length (per unit RNFL bundle area), (μm^-1)	mean L_am/A_b	0.24	0.3670	0.23	0.5811