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. Author manuscript; available in PMC: 2010 Nov 20.
Published in final edited form as: Circ Res. 2009 Oct 8;105(11):1110–1117. doi: 10.1161/CIRCRESAHA.109.200741

Figure 2.

Figure 2

Examination of the cardiac hypertrophic response in ASK1 TG mice following stimulation. A, Quantitation of HW/BW in 3 month-old Wt, tTA, or DTG mice subjected to TAC or sham procedure for 2 weeks. Number of mice analyzed is shown in the bars. *P< 0.05 versus respective sham group. B, Systolic pressure gradient (PG) across the aortic constriction. C, Myocyte surface area from heart histological sections of the mice shown in A. Surface areas of 500 cells per mouse were measured in random fields in 3 mice per group. *P< 0.05 versus sham. D, Fractional shortening (FS) of the mice shown in A. E, Quantitation of HW/BW in 3 month-old WT, tTA, or DTG mice implanted with PBS or isoproterenol (ISO) containing Alzet mini-pumps (60 mg/kg/day) for 2 weeks. *P< 0.05 versus PBS. F, Myocyte surface area from histological sections of the mice shown in E. Surface areas of 500 cells per mouse were measured in random fields in 3 mice per group. *P < 0.05 versus PBS.