Table 1.

Behavioral effects of the intraperitoneal administration of Δ⁹-tetrahydrocannabinol (Δ⁹-THC), amphetamine, and morphine in the mouse tetrad assay

Treatment	Locomotor	Catalepsy	Rectal Temperature Change (°C)	Tail-Flick Latency (%MPE)	Hotplate Latency (%MPE)
Δ9-THC (mg/kg)
0	1329 ± 175.9	1.44 ± 0.28	− 0.73 ± 0.12	1.50 ± 1.85	6.37 ± 2.51
10	190.9 ± 33.8***	14.40 ± 4.16	− 2.05 ± 0.25	6.52 ± 2.00	29.04 ± 5.37*
20	260.4 ± 41.4***	47.88 ± 20.04***	−3.87 ± 0.45***	28.24 ± 11.12*	36.33 ± 6.72***
40	194.0 ± 49.2***	37.70 ± 14.64***	−3.48 ± 0.28***	51.96 ± 13.22***	38.18 ± 4.05***
Amphetamine (mg/kg)
0	1676 ± 238.6	1.88 ±0.58	−0.39 ±0.12	5.92 ± 2.45	11.12 ± 1.17
5	5337 ± 713.7 ***	1.63 ± 0.50	1.11 ± 0.15***	65.63 ±12.60**	19.29 ± 2.70*
20	1682 ± 423.3	2.63 ±0.65	1.61 ± 0.25***	78.63 ± 15.65***	27.84 ±2.66***
Morphine (mg/kg)
0	1676 ± 238.6	1.88 ± 0.58	−0.39 ± 0.12	5.92 ± 2.45	11.12 ± 1.17
5	688.7 ± 136.9***	2.25 ±0.86	−0.71 ±0.18	60.24 ± 19.00**	16.01 ± 2.97
10	274.3 ± 44.68***	2.17 ± 0.98	−0.73 ± 0.13	89.54 ±10.46***	30.86 ± 2.92*
20	271.4 ±39.71***	1.63 ±0.42	−2.83 ±0.36***	100.00 ± 0.00***	69.66 ± 8.06***

^*p<0.05,

^**p<0.01,

^***p<0.001 versus the vehicle, Dunnett’s post hoc test