Table 2.

Behavioral effects of the intraperitoneal administration of nutmeg extracts in the mouse tetrad assay

Treatment	Locomotor	Catalepsy	Rectal Temperature	Tail-Flick	Hotplate
Vehicle	829.4±232.9	1.29±0.18	−0.65±0.10	5.29±7.86	2.16±2.99
Dichloromethane Extract (DE)
100mg/kg	909.5±265	1.13±0.13	−1.54±0.40*	2.89±3.744	2.45±3.57
300mg/kg	1304±200.7	1.86±0.86	−1.18±0.23***	8.45±5.95	17.84±2.65**
500mg/kg	1210±88.18	1.86±0.55	−1.53±0.31***	−2.76±3.97	9.35±2.96
Methanolic Extract (ME)
100mg/kg	1343±123.1	1.38±0.38	−1.54±0.40	−1.19±3.44	−0.99±1.62
300mg/kg	671.4±147.7	3.00±1.02	−1.36±0.39	−4.84±3.50	8.65±2.36
500mg/kg	1025±328.2	1.60±0.50	−2.22±0.59*	4.92±1.70	19.22±6.54*
n-Hexane Extract (HE)
100mg/kg	630.6±199.8	1.25±0.16	−2.21±0.37***	0.45±3.59	6.551±3.592
300mg/kg	1046±121.5	3.25±1.05	−1.68±0.38*	9.57±11.49	20.47±3.134***
500mg/kg	1054±114.2	1.00±0.00	−0.51±0.10	3.82±2.81	14.34±2.531*
Defatted Methanolic Extract (DME)
100mg/kg	1646±145.10 **	1.25±0.16	−0.23±0.06	10.59±1.854	25.16±2.86***
300mg/kg	285±137.70**	1.375±0.38	−1.31±0.37	6.37±2.45	18.41±2.99*
500mg/kg	196.6±77.26**	1.67±0.49	−3.38±0.53***	53.91±19.17***	30.37±4.88***

^*p<0.05,

^**p<0.01,

^***p<0.001 versus the vehicle, Dunnett’s post hoc test