Table 3.

Behavioral effects of oral administration of nutmeg extracts in mouse tetrad assay

Treatment	Locomotor	Catalepsy	Rectal Temperature	Tail-Flick	Hotplate
Vehicle	1139±309.0	1±0	−0.50±0.24	−4.51±5.17	12.91±1.90
Dichloromethane Extract (DE)
500mg/kg	4320±739.5***	1.25±0.25	−0.73±0.10	5.62±2.29	20.43±1.47
1000mg/kg	1379±111.4	1.71±0.47	−0.48±0.20	1.42±2.82	16.25±4.06
Methanolic Extract (ME)
500mg/kg	5516±875.7***	1.38±0.38	−0.38±0.08	3.18±4.19	5.36±1.24
1000mg/kg	2339±515.4	1.25±0.25	−0.45±0.13	5.08±3.50	9.61±2.78
n-Hexane Extract (HE)
500mg/kg	3123±674.8**	1.38±0.26	−0.73±0.12	3.62±3.02	19.27±1.40*
1000mg/kg	2323±206.4	1.38±0.38	−0.48±0.11	9.02±4.02	9.32±1.54
Defatted Methanolic Extract (DME)
500mg/kg	852.7±205.6	1.13±0.13	−0.23±0.09	1.54±2.46	11.08±2.04
1000mg/kg	908.2±207.6	2.43±1.13	−0.23±0.06	7.41±6.46	10.28±0.96

^*p<0.05,

^**p<0.01,

^***p<0.001 versus the vehicle, Dunnett’s post hoc test