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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Free Radic Biol Med. 2009 Sep 12;47(11):1539–1552. doi: 10.1016/j.freeradbiomed.2009.09.003

Figure 1.

Figure 1

Free radical-induced cyclooxygenation of PA-PC is postulated to generate a series of 8 structurally isomeric families each comprised of 8 isoLG stereoisomers through isoprostanoid endoperoxide intermediates. Two of these 64 different isomers, members of the isoLGE2 and isoLGD2 families of stereoisomers, are identical with products of the cyclooxygenase pathway, namely LGE2 and LGD2. Hydroxylactam (HL) end products, together with the corresponding lactams and pyrroles, are generated by the reaction of isoLGs with phosphatidylethanolamines. PLA2-catalyzed selective lipolysis of these PE adducts converts them into the corresponding 2-lyso-PEs.