TABLE 2.

Pharmacokinetic Parameters of Mycophenolic Acid and Glucuronide Metabolite After MMF Administration in Combination With CsA or TRL (n = 8)

	CsA		TRL		P
	Mean ± SD (range)	CV%	Mean ± SD (range)	CV%
MPA
AUC0–12 (mg·hr/L)	45.2 ± 15.9 (20.8–68.4)	35	66.2 ± 29.2 (34.7–114.8)	44	0.012
C0 (mg/L)	2.3 ± 2.1 (0.6–6.7)	91	4.6 ± 3.7 (1.6–12.4)	81	0.008
Cmax (mg/L)	15.0 ± 6.9 (8.0–28.7)	46	16.1 ± 9.7 (5.7–30.2)	60	0.773
Tmax (h)	1.0 ± 0.4 (0.5–2.0)	41	1.2 ± 0.8 (0.5–3.0)	67	0.461
CL/F (L h−1 kg−1)	0.21 ± 0.05 (0.15–0.31)	25	0.15 ± 0.05 (0.09–0.21)	30	0.004
MPAG
AUC0–12 (mg·hr/L)	1180 ± 291 (878–1663)	25	913 ± 299 (695–1587)	33	0.009
C0 (mg/L)	77 ± 21 (56–109)	28	66 ± 29 (30–125)	43	0.096
Cmax (mg/L)	144 ± 36 (92–199)	25	102 ± 35 (68–180)	34	0.019
Tmax (h)	2.7 ± 1.0 (1.9–4.0)	35	2.1 ± 1.1 (1.0–4.0)	53	0.142

CV, coefficient of variation.