Table 1.
Experimental design. Tumor incidence is summarized by dose and quartile. A complete dataset at the tank level is included in the supporting information (Table S-1).
| Experiment quarter |
DBP dose (ppm diet) |
Replicate groups necropsied |
Animals necropsied |
Histological liver neoplasia |
Incidence | Stomach neoplasia |
Incidence |
|---|---|---|---|---|---|---|---|
| 1 | 0 | 23 | 2097 | 2 | 0.00095 | 5 | 0.00236 |
| 2 | 0 | 22 | 2056 | 4 | 0.00195 | 5 | 0.00236 |
| 3 | 0 | 25 | 2348 | 2 | 0.00085 | 1 | 0.00043 |
| 4 | 0 | 21 | 1862 | 2 | 0.00107 | 4 | 0.00200 |
| 1 | 0.45 | 24 | 2139 | 1 | 0.00047 | 9 | 0.00420 |
| 2 | 0.45 | 22 | 2021 | 4 | 0.00198 | 3 | 0.00148 |
| 3 | 0.45 | 25 | 2380 | 2 | 0.00084 | 5 | 0.00210 |
| 4 | 0.45 | 25 | 2208 | 5 | 0.00226 | 3 | 0.00136 |
| 1 | 1.27 | 14 | 1280 | 4 | 0.00313 | 2 | 0.00138 |
| 2 | 1.27 | 18 | 1672 | 5 | 0.00299 | 4 | 0.00234 |
| 3 | 1.27 | 19 | 1814 | 1 | 0.00055 | 3 | 0.00165 |
| 4 | 1.27 | 19 | 1663 | 2 | 0.00120 | 3 | 0.00180 |
| 1 | 3.57 | 8 | 737 | 9 | 0.01221 | 4 | 0.00513 |
| 2 | 3.57 | 14 | 1253 | 11 | 0.00878 | 7 | 0.00559 |
| 3 | 3.57 | 14 | 1327 | 8 | 0.00603 | 2 | 0.00151 |
| 4 | 3.57 | 14 | 1218 | 9 | 0.00739 | 3 | 0.00246 |
| 1 | 10.1 | 3 | 275 | 9 | 0.03273 | 1 | 0.00364 |
| 2 | 10.1 | 4 | 361 | 25 | 0.06925 | 1 | 0.00277 |
| 3 | 10.1 | 5 | 488 | 27 | 0.05533 | 2 | 0.00410 |
| 4 | 10.1 | 5 | 434 | 24 | 0.05530 | 4 | 0.00922 |
| 1 | 28.4 | 2 | 182 | 25 | 0.13736 | 11 | 0.06044 |
| 2 | 28.4 | 3 | 278 | 73 | 0.26259 | 11 | 0.03957 |
| 3 | 28.4 | 4 | 387 | 48 | 0.12403 | 19 | 0.04909 |
| 4 | 28.4 | 4 | 364 | 95 | 0.26099 | 15 | 0.04121 |
| 1 | 80 | 2 | 190 | 88 | 0.46316 | 65 | 0.342 |
| 2 | 80 | 2 | 186 | 91 | 0.48925 | 46 | 0.247 |
| 3 | 80 | 3 | 292 | 144 | 0.49315 | 76 | 0.260 |
| 4 | 80 | 3 | 263 | 138 | 0.52471 | 86 | 0.327 |
| 1 | 225 | 1 | 93 | 63 | 0.67742 | 68 | 0.731 |
| 2 | 225 | 1 | 85 | 56 | 0.65882 | 71 | 0.835 |
| 3 | 225 | 2 | 180 | 100 | 0.55556 | 127 | 0.706 |
| 4 | 225 | 2 | 183 | 99 | 0.54098 | 129 | 0.705 |