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. Author manuscript; available in PMC: 2010 Dec 14.
Published in final edited form as: J Infect Dis. 2009 Dec 15;200(12):1936–1943. doi: 10.1086/648091

Figure 3. Comparison of U.S. B. burgdorferi isolates and Slovenian B. afzelii and B. garinii isolates.

Figure 3

Normal human macrophages were stimulated for 48 h with 10 B. burgdorferi isolates from EM lesions of U.S. patients, or 10 B. afzelii isolates or 10 B. garinii isolates from EM lesions of Slovenian patients. A) Chemokine and B) cytokine levels were determined in culture supernatants using bead-based Multiplex assays. All 30 isolates were tested with macrophages from each of the 9 healthy donors. The values from the 9 experiments were then averaged. The box in the graph represent 25th and 75th percentiles, the line in the box is the median value and the lines outside the box represent 5th and 95th percentiles. Except for CCL2 and IL-1β, B. burgdorferi isolates induced significantly higher levels of chemokines and cytokines than B. afzelii and B. garinii isolates. *P ≤ 0.05, **P ≤ 0.01 ***P ≤ 0.001.