Table 3.

Characteristics of Anti-transducin Retinal Phenotype in Comparison to Anti-Recoverin and Anti-Enolase Phenotypes

Features	Anti-recoverin	Anti-enolase	Anti-transducin-α
Average Age *	69	64	57
Onset	Acute, sudden	Subacute, chronic	Sudden progressive
Ocular symmetry	Usually symmetric	Often symmetric	Symmetric
Presentation	Severe central and peripheral vision loss	Mostly central vision loss	Mild, patchy to global acuity and field loss
Course	Rapid rod and cone loss	Mild to severe progression	Mild progression
Full Field ERG	Severe equal rod and cone loss	Normal to severe cone loss	Reduced rod more than cone dysfunction
Multifocal ERG	Severely abnormal	Mildly to severely abnormal	Decreased amplitudes, Delayed timing
Association with cancer	Almost 100%	About 40%	About 25 %
Relationship of cancer diagnosis of retinopathy onset	Retinopathy precedes diagnosis of cancer by months	Retinopathy develops after diagnosis of cancer by months to years	Retinopathy develops after diagnosis of cancer by months to years**

^*Average age of patients tested in our laboratory

^**In one patient, the presence of autoantibodies preceded diagnose with cancer