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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Int J Gynaecol Obstet. 2009 Aug 28;107(3):202–207. doi: 10.1016/j.ijgo.2009.07.037

Table 3.

Effect of antibiotics versus placebo on maternal health conditions during pregnancy and the first 3 months post partum

Women with conditions
during study follow-up
Not adjusted for site Adjusted for site

Medical Conditions Antibiotics Placebo Odds ratio c (95% CI) P-value Odds ratio c (95%
CI)
P value
HIV-infected cohort
Fever >2 weeks a 57 50 1.07 (0.73–1.56) 0.74 1.07 (0.73–1.56) 0.73
Diarrhea in last 2 weeks a 82 68 1.14 (0.81–1.61) 0.44 1.14 (0.81–1.60) 0.45
Cough >2 weeks a 87 76 0.37 1.16 (0.84–1.60) 0.38
1.16 (0.8–1.60)
Vaginal discharge a 170 143 1.16 (0.92–1.47) 0.20 1.17 (0.93–1.48) 0.17
Oral thrush a 28 24 1.22 (0.68–2.16) 0.50 1.21 (0.68–2.14) 0.52
Admission to hospital a 88 82 0.96 (0.70–1.31) 0.78 0.95 (0.70–1.30) 0.76
Mastitis b 21 22 0.92 (0.50–1.69) 0.79 0.92 (0.50–1.70) 0.80
Puerperal sepsis 10 18 0.53 (0.24–1.15) 0.11 0.52 (0.24–1.14) 0.11
Fever during labor>38
degrees b, d
9 6 1.46 (0.52–4.12) 0.48
Admitted to postpartum
ward b
50 64 0.74 (0.50–1.09) 0.13 0.74 (0.50–1.09) 0.13
Fever postpartum b 7 8 0.85 (0.31–2.35) 0.75 0.85 (0.31–2.36) 0.75
Antenatal hemorrhage b, d 5 3 1.62 (0.39–6.83) 0.51
Postpartum hemorrhage b 3 7 0.41 (0.11–1.61) 0.20 0.41 (0.11–1.61) 0.20
Hypertension without
proteinuria b
7 9 0.75 (0.28–2.04) 0.58 0.75 (0.28–2.03) 0.58
Hypertension with
proteinuria b, d
8 2 3.92 (0.83–18.54) 0.08
HIV-uninfected cohort
Mastitis b
1 3 0.34 (0.03–3.31) 0.35 0.34 (0.03–3.37) 0.36
Admitted to postnatal
ward b
6 7 0.89 (0.29–2.74) 0.84 0.86 (0.28–2.66) 0.79
Hypertension without
proteinuria b, d
2 1 2.15 (0.19–23.98) 0.53
a

Odds ratio estimate, 95% confidence interval and P values from GEE model.

b

Odds ratio estimate, 95% confidence interval and P values from logistic regression.

c

The odds ratio calculations used the placebo arm as the reference group.

d

No comparisons adjusting for site were done due to zero incidence in certain site and arm combinations.