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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2009 Aug 18;241(2):127–134. doi: 10.1016/j.taap.2009.08.012

Figure 7. Effect of PI3 kinase inhibition on DMBA-induced ovotoxicity.

Figure 7

Ovaries from PND4 F344 rats were cultured with vehicle control medium (CT) or medium containing DMBA (1 μM) in the presence or absence of LY294002 (LY29; 20 μM) for 6d. Following incubation, ovaries were collected and processed for histological evaluation as described in materials and methods. (A) Primordial and (B) small primary follicles were classified and counted. Values are mean ± SE total follicles counted/ovary, n=4–5; Different letters differ from one another within each group; P < 0.05.