Table 1.

Effects of Spironolactone on Physiological Measurements After PNx or Infusion of MBG

Group	Sham (n=8)	S (n=8)	PNx (n=10)	PNx+S (n=6)	MBG (n=8)	MBG+S (n=6)
Systolic BP
SBP 0 wk, mm Hg	119±3	108±4^*	112±5	115±3	118±3	114±2
SBP 1 wk, mm Hg	123±4	101±4^*	160±4^†	144±5^*^‡	151±5^†	138±1^*^∥
SBP 2 wk, mm Hg	125±3	112±3^*	185±6^†	157±4^†^§	165±8^†	129±4^¶
SBP 3 wk, mm Hg	122±3	101±3^*	183±3^†	148±3^†^§	154±6^†	125±7^¶
SBP 4 wk, mm Hg	125±1	99±3	169±2^†	130±3^§	162±1^†	123±1^¶
Heart weight
BW, g	469±12	460±9	460±18	462±11	503±16	502±14
HW, g	1.32±0.03	1.30±0.2	1.54±0.06^†	1.30±0.03^§	1.68±0.06^†	1.36±0.05^¶
HW/BW, ×10³	2.95±0.05	2.82±0.09	3.46±0.08^*	2.83±0.07^§	3.40±0.09^*	2.70±0.09^¶
Plasma measurements
Creatinine, mg/dL	0.39±0.02	0.38±0.03	0.60±0.07^*	0.63±0.05^*	0.41±0.03	0.38±0.02
Potassium, mEq/L	5.8±0.3	5.6±0.4	6.3±0.3	6.6±0.4	6.2±0.3	6.1±0.3
MBG, pmol/L	371±43	321±86	903±135^†	994±154^†	887±140^†	762±98^†
Aldosterone, pg/mL	280±33	249±55	1890±277^†	1750±292^†	245±20	261±45

S indicates spironolactone; SBP, systolic BP measured in conscious animals with a tail cuff on weekly intervals after surgery; BW, body weight; HW, heart weight determined at the time of euthanasia.

P<0.05 vs sham.

^†

P<0.01 vs sham.

^‡

P<0.05 vs PNx.

^§

P<0.01 vs PNx.

^∥

P<0.05 vs MBG.

^¶

P<0.01 vs MBG.