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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Hypertension. 2009 Nov 2;54(6):1313–1320. doi: 10.1161/HYPERTENSIONAHA.109.140038

Table 1.

Effects of Spironolactone on Physiological Measurements After PNx or Infusion of MBG

Group Sham (n=8) S (n=8) PNx (n=10) PNx+S (n=6) MBG (n=8) MBG+S (n=6)
Systolic BP
    SBP 0 wk, mm Hg 119±3 108±4* 112±5 115±3 118±3 114±2
    SBP 1 wk, mm Hg 123±4 101±4* 160±4 144±5* 151±5 138±1*
    SBP 2 wk, mm Hg 125±3 112±3* 185±6 157±4§ 165±8 129±4
    SBP 3 wk, mm Hg 122±3 101±3* 183±3 148±3§ 154±6 125±7
    SBP 4 wk, mm Hg 125±1 99±3 169±2 130±3§ 162±1 123±1
Heart weight
    BW, g 469±12 460±9 460±18 462±11 503±16 502±14
    HW, g 1.32±0.03 1.30±0.2 1.54±0.06 1.30±0.03§ 1.68±0.06 1.36±0.05
    HW/BW, ×103 2.95±0.05 2.82±0.09 3.46±0.08* 2.83±0.07§ 3.40±0.09* 2.70±0.09
Plasma measurements
    Creatinine, mg/dL 0.39±0.02 0.38±0.03 0.60±0.07* 0.63±0.05* 0.41±0.03 0.38±0.02
    Potassium, mEq/L 5.8±0.3 5.6±0.4 6.3±0.3 6.6±0.4 6.2±0.3 6.1±0.3
    MBG, pmol/L 371±43 321±86 903±135 994±154 887±140 762±98
    Aldosterone, pg/mL 280±33 249±55 1890±277 1750±292 245±20 261±45

S indicates spironolactone; SBP, systolic BP measured in conscious animals with a tail cuff on weekly intervals after surgery; BW, body weight; HW, heart weight determined at the time of euthanasia.

*

P<0.05 vs sham.

P<0.01 vs sham.

P<0.05 vs PNx.

§

P<0.01 vs PNx.

P<0.05 vs MBG.

P<0.01 vs MBG.