Table 1.
Effects of Spironolactone on Physiological Measurements After PNx or Infusion of MBG
Group | Sham (n=8) | S (n=8) | PNx (n=10) | PNx+S (n=6) | MBG (n=8) | MBG+S (n=6) |
---|---|---|---|---|---|---|
Systolic BP | ||||||
SBP 0 wk, mm Hg | 119±3 | 108±4* | 112±5 | 115±3 | 118±3 | 114±2 |
SBP 1 wk, mm Hg | 123±4 | 101±4* | 160±4† | 144±5*‡ | 151±5† | 138±1*∥ |
SBP 2 wk, mm Hg | 125±3 | 112±3* | 185±6† | 157±4†§ | 165±8† | 129±4¶ |
SBP 3 wk, mm Hg | 122±3 | 101±3* | 183±3† | 148±3†§ | 154±6† | 125±7¶ |
SBP 4 wk, mm Hg | 125±1 | 99±3 | 169±2† | 130±3§ | 162±1† | 123±1¶ |
Heart weight | ||||||
BW, g | 469±12 | 460±9 | 460±18 | 462±11 | 503±16 | 502±14 |
HW, g | 1.32±0.03 | 1.30±0.2 | 1.54±0.06† | 1.30±0.03§ | 1.68±0.06† | 1.36±0.05¶ |
HW/BW, ×103 | 2.95±0.05 | 2.82±0.09 | 3.46±0.08* | 2.83±0.07§ | 3.40±0.09* | 2.70±0.09¶ |
Plasma measurements | ||||||
Creatinine, mg/dL | 0.39±0.02 | 0.38±0.03 | 0.60±0.07* | 0.63±0.05* | 0.41±0.03 | 0.38±0.02 |
Potassium, mEq/L | 5.8±0.3 | 5.6±0.4 | 6.3±0.3 | 6.6±0.4 | 6.2±0.3 | 6.1±0.3 |
MBG, pmol/L | 371±43 | 321±86 | 903±135† | 994±154† | 887±140† | 762±98† |
Aldosterone, pg/mL | 280±33 | 249±55 | 1890±277† | 1750±292† | 245±20 | 261±45 |
S indicates spironolactone; SBP, systolic BP measured in conscious animals with a tail cuff on weekly intervals after surgery; BW, body weight; HW, heart weight determined at the time of euthanasia.
P<0.05 vs sham.
P<0.01 vs sham.
P<0.05 vs PNx.
P<0.01 vs PNx.
P<0.05 vs MBG.
P<0.01 vs MBG.