Table 2.

Effects of Spironolactone on Left Ventricular Functional Measurements After PNx or Infusion of MBG

Group	Sham (n=12)	S (n=10)	PNx (n=12)	PNx+S (n=8)	MBG (n=10)	MBG+S (n=8)
EDV, μL	193±15	197±22	129±9†	200±15§	147±11*	207±181¶
ESV, μL	95±9	97±5	39±7†	85±10§	57±6†	99±12∥
SV, μL	115±8	120±16	106±10	109±9	98±9	108±11
EF, %	57±2	55±3	76±3†	54±8†§	64±3*	60±4
Tau, ms	11.9±0.7	10.6±0.9	17.6±2.0*	13.3±1.2‡	12.8±0.9	9.9±1.4
EDPVR, mm Hg/μL	0.031±0.004	0.031±0.001	0.046±0.006*	0.027±0.005‡	0.042±0.004*	0.031±0.005∥

S indicates spironolactone; EDV, end-diastolic volume; ESR, end-systolic volume; SV, stroke volume; EF, ejection fraction; Tau, time constant for isovolumic relaxation; EDPVR, slope of the regression line fit to the end-diastolic pressure and volume data generated by inferior vena caval constriction.

^*P<0.05 vs sham.

^†P<0.01 vs sham.

^‡P<0.05 vs PNx.

^§P<0.01 vs PNx.

^∥P<0.05 vs MBG.

^¶P<0.01 vs MBG.