Table 1.
HIV-derived CTL epitopes used in vaccine design and synthesis
HLA-A2 Epitopes | HLA-A3 Epitopes | HLA-B7 Epitopes | |||
---|---|---|---|---|---|
Protein Designation1 | Amino Acid Sequence1 | Protein Designation | Amino Acid Sequence | Protein Designation | Amino Acid Sequence |
Pol 498 | ILKEPVHGV | Env 47 | VTVYYGVPVWK | Nef 94 | FPVRPQVPL |
Gag 386 | VLAEAMSQV | Pol 929 | QMAVFIHNFK | Gag 545 | YPLASLRSLF |
Pol 448 | KLVGKLNWA | Pol 98 | VTIKIGGQLK | Rev 75 | VPLQLPPL |
Env 134 | KLTPLCVTL | Pol 971 | KIQNFRVYYR | Env 259 | IPIHYCAPA |
Vpr 62 | RILQQLLFI | Pol 347 | AIFQSSMTK | Gag 237 | HPVHAGPIA |
Nef 221 | LTFGWCFKL | Pol 722 | KVYLAWPAHK | Pol 893 | IPYNPQSQGW |
Gag 271 | MTNNPPIPV | Env 61 | TTLFCASDAK | Env 250 | CPKVSFEPI |
Epitopes are designed based on their location within HIV viral gene products using gene name and the position of the first amino acid using an internal consensus sequence specific for the data base used. Sequences are shown using the single letter amino acid designations.