Figure 1. Midgut cell death occurs in the absence of the main effector and initiator caspases.
Histolysis of (A) wild type (WT); (B) dcp-1Prev1; droncI24/I29 driceΔ1; and (C) strica4; droncI24/I29 driceΔ1 midguts occur similarly. Detection of TUNEL-positive nuclei (left) from -4 to -1 hr RPF larvae and Hoechst staining of DNA (middle). Morphology of midgut at +4 hr RPF, note the contraction of gastric caeca (arrows) as midguts undergo PCD.