Table 1.
Selected genes modified with statistical significance (p<0.05) for Snail over-expressing as compared to vector control NSCLC cells. (↑=up-regulation, ↓=down-regulation)
| Probe set | Gene | Accession | P value |
|---|---|---|---|
| Angiogenesis | |||
| 203002_at | angiomotin like 2 (↑) | NM_016201 | 0.044 |
| 210845_s_at | plasminogen activator, urokinase receptor (↑) | U08839 | 0.038 |
| 218520_at | TANK-binding kinase 1 (↑) | NM_013254 | 0.032 |
| 200628_s_at | tryptophanyl-tRNA synthetase (↑) | M61715 | 0.045 |
| 200677_at | pituitary tumor-transforming 1 interacting protein (↑) | NM_004339 | 0.029 |
| 204773_at | interleukin 11 receptor, alpha (↑) | NM_004512 | 0.044 |
| 227095_at | leptin receptor (↑) | AU151151 | 0.028 |
| 201109_s_at | thrombospondin 1 (↑) | AV726673 | 0.048 |
| 201110_s_at | thrombospondin 1 (↑) | NM_003246 | 0.048 |
| 211547_s_at | platelet-activating factor acetylhydrolase, isoform Ib, αsubunit 45kDa (↑) | L13387 | 0.049 |
| 201286_at | syndecan 1 (↓) | Z48199 | 0.04 |
| 201287_s_at | syndecan 1 (↓) | NM_002997 | 0.034 |
| Invasion and metastasis | |||
| 234001_s_at | ADP-ribosylation factor GTPase activating protein 1 (↑) | AL137744 | 0.034 |
| 214088_s_at | fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group included) (↓) | AW080549 | 0.021 |
| 221754_s_at | coronin, actin binding protein, 1B (↓) | AI341234 | 0.023 |
| Cell cycle | |||
| 202723_s_at | forkhead box O1A (rhabdomyosarcoma) (↑) | AW117498 | 0.038 |
| 204604_at | PFTAIRE protein kinase 1 (↑) | NM_012395 | 0.034 |
| 1554408_a_at | thymidine kinase 1, soluble (↓) | BC007986 | 0.008 |
| Tumor suppressor | |||
| 213473_at | BRCA1 associated protein (↑) | AL042733 | 0.042 |
| 1554006_a_at | lethal giant larvae homolog 2 (Drosophila) (↓) | BC006503 | 0.044 |