Table 1.
Means* and ranges of individual and grouped urinary estrogens and estrogen metabolites (EM), expressed as absolute concentrations (pmol/mg creatinine), percent of the total EM, and selected EM ratios; first collection.
| EM measure | Mean (5th-95th percentile) |
||
|---|---|---|---|
| pmol/mg creatinine | % of total | ||
| Total EM | 219 (117-454) | ||
| Parent EM | 44.0 (21.6-84.4) | 21.1 (12.0-33.9) | |
| Estrone | 31.0 (13.7-62.3) | 14.97 (7.85-25.03) | |
| Estradiol | 12.3 (5.40-27.3) | 6.15 (2.54-12.67) | |
| Catechol EM | 68.2 (22.9-214) | 35.36 (11.79-64.57) | |
| 2-Catechol EM | 59.7 (18.1-198) | 31.22 (10.09-55.34) | |
| 2-Hydroxyestrone | 53.3 (16.4-179) | 28.02 (9.18-51.10) | |
| 2-Hydroxyestradiol | 5.94 (1.80-20.8) | 3.20 (0.96-6.09) | |
| 4-Catechol EM | 4-Hydroxyestrone | 7.57 (2.24-25.7) | 4.14 (0.99-8.39) |
| Methylated Catechol EM | 8.72 (2.91-26.5) | 4.65 (1.47-9.27) | |
| Methylated 2-Catechol EM | 8.46 (2.76-24.8) | 4.54 (1.38-9.23) | |
| 2-Methoxyestrone | 5.93 (1.93-19.7) | 3.25 (0.86-7.36) | |
| 2-Methoxyestradiol | 0.79 (0.30-2.14) | 0.40 (0.17-0.74) | |
| 2-Hydroxyestrone-3-methyl ether | 1.41 (0.42-4.39) | 0.80 (0.25-1.55) | |
| Methylated 4-Catechol EM | 0.20 (0.08-0.57) | 0.11 (0.04-0.24) | |
| 4-Methoxyestrone | 0.16 (0.06-0.47) | 0.09 (0.03-0.21) | |
| 4-Methoxyestradiol | 0.04 (0.01-0.14) | 0.02 (0.00-0.07) | |
| 2-Hydroxylation Pathway EM | 69.6 (22.0-209) | 35.76 (12.08-61.51) | |
| 4-Hydroxylation Pathway EM | 7.85 (2.37-26.2) | 4.25 (1.11-8.44) | |
| 16-Hydroxylation Pathway EM | 76.9 (32.6-184) | 38.88 (17.16-67.15) | |
| 16α-Hydroxyestrone | 12.9 (4.70-40.1) | 7.09 (1.70-14.59) | |
| Estriol | 32.6 (11.1-93.2) | 17.44 (5.68-34.12) | |
| 17-Epiestriol | 2.19 (0.52-10.5) | 1.51 (0.24-5.28) | |
| 16-Ketoestradiol | 18.2 (7.99-43.9) | 9.21 (3.47-15.57) | |
| 16-Epiestriol | 7.30 (3.50-16.3) | 3.65 (1.60-6.33) | |
|
Ratios |
|||
| Ratios | 4-Catechol/2-Catechols | 0.13 (0.06-0.29) | |
| 2-Catechols/16-Pathway | 0.78 (0.15-3.38) | ||
| Catechols/16-Pathway | 0.89 (0.18-3.96) | ||
| 4-Pathway/2-Pathway | 0.11 (0.05-0.24) | ||
| 2-Pathway/16-Pathway | 0.90 (0.19-3.80) | ||
| 4-Pathway/16-Pathway | 0.10 (0.02-0.46) | ||
| 2,4-Pathway/16-Pathway | 1.01 (0.21-4.27) | ||
| 2-Pathway/4,16-Pathway | 0.78 (0.18-2.63) | ||
| 2-Catechols/Methylated 2-Catechols | 7.06 (2.73-18.3) | ||
| 4-Catechol/Methylated 4-Catechols | 36.2 (7.98-146) | ||
| Catechols/Methylated Catechols | 7.80 (3.06-20.6) | ||
| Parent Estrogens/Estrogen Metabolites | 0.26 (0.14-0.51) | ||
*
Means/ranges are geometric for absolute and ratio measures, arithmetic for % measures.