Table 4.
Intraclass correlation coefficients (95% confidence intervals) for individual and grouped estrogens and estrogen metabolites (EM), expressed as absolute concentrations, percent of total EM, and selected EM ratios.
| ICC (95% CI) |
|||
|---|---|---|---|
| Analyte | Absolute Concentration | % of Total EM | |
| Parent EM | 0.52 (0.41-0.62) | 0.64 (0.54-0.72) | |
| Estrone | 0.52 (0.42-0.63) | 0.67 (0.58-0.75) | |
| Estradiol | 0.49 (0.39-0.60) | 0.52 (0.42-0.62) | |
| Catechol EM | 0.72 (0.64-0.79) | 0.85 (0.80-0.89) | |
| 2-Catechol EM | 0.72 (0.64-0.78) | 0.84 (0.79-0.88) | |
| 2-Hydroxyestrone | 0.71 (0.63-0.78) | 0.83 (0.78-0.87) | |
| 2-Hydroxyestradiol | 0.67 (0.59-0.75) | 0.68 (0.60-0.76) | |
| 4-Catechol EM | 4-Hydroxyestrone | 0.58 (0.48-0.67) | 0.51 (0.41-0.62) |
| Methylated Catechol EM | 0.61 (0.51-0.69) | 0.64 (0.55-0.73) | |
| Methylated 2-Catechol EM | 0.62 (0.52-0.70) | 0.65 (0.56-0.73) | |
| 2-Methoxyestrone | 0.62 (0.52-0.71) | 0.67 (0.59-0.75) | |
| 2-Methoxyestradiol | 0.51 (0.41-0.62) | 0.53 (0.42-0.63) | |
| 2-Hydroxyestrone-3-methyl ether | 0.51 (0.40-0.61) | 0.50 (0.40-0.61) | |
| Methylated 4-Catechol EM | 0.25 (0.15-0.39) | 0.27 (0.17-0.40) | |
| 4-Methoxyestrone | 0.27 (0.17-0.41) | 0.30 (0.20-0.43) | |
| 4-Methoxyestradiol | 0.14 (0.06-0.30) | 0.13 (0.05-0.29) | |
| 2-Pathway EM | 0.72 (0.64-0.78) | 0.85 (0.80-0.89) | |
| 4-Pathway EM | 0.57 (0.47-0.67) | 0.51 (0.40-0.61) | |
| 16-Pathway EM | 0.52 (0.41-0.62) | 0.82 (0.76-0.86) | |
| 16α-Hydroxyestrone | 0.46 (0.35-0.57) | 0.64 (0.55-0.72) | |
| Estriol | 0.54 (0.44-0.64) | 0.77 (0.70-0.83) | |
| 17-Epiestriol | 0.50 (0.39-0.60) | 0.56 (0.46-0.65) | |
| 16-Ketoestradiol | 0.42 (0.31-0.53) | 0.59 (0.49-0.68) | |
| 16-Epiestriol | 0.45 (0.34-0.56) | 0.56 (0.46-0.66) | |
| Total EM | 0.39 (0.28-0.51) | ||
|
EM Ratios |
|||
| 4-Catechol/2-Catechols | 0.21 (0.11-0.35) | ||
| 2-Catechols/16-Pathway | 0.83 (0.78-0.88) | ||
| Catechols/16-Pathway | 0.83 (0.77-0.87) | ||
| 4-Pathway/2-Pathway | 0.21 (0.11-0.35) | ||
| 2-Pathway/16-Pathway | 0.83 (0.77-0.87) | ||
| 4-Pathway/16-Pathway | 0.70 (0.62-0.77) | ||
| 2,4-Pathway/16-Pathway | 0.85 (0.80-0.89) | ||
| 2-Pathway/4,16-Pathway | 0.84 (0.79-0.88) | ||
| 2-Catechols/Methylated 2-Catechols | 0.58 (0.48-0.67) | ||
| 4-Catechol/Methylated 4-Catechols | 0.42 (0.31-0.54) | ||
| Catechols/Methylated Catechols | 0.60 (0.50-0.69) | ||
| Parent Estrogens/Estrogen Metabolites | 0.65 (0.55-0.73) | ||