Figure 6.
Response of spontaneous contractile activity of circular muscle of rat jejunum to EFS at A) 3 Hz, B) 6 Hz, and C) 20 Hz. The combination of VIP antagonist and L-NNA increased the response to EFS at 3 Hz in middle-aged but not in young rats. In contrast, at 6 Hz, the combination of VIP antagonist and L-NNA increased the EFS response in both groups. The Sub P antagonist prevented the excitatory EFS response at 20 Hz in both groups; *p<0.05 compared to baseline contractile activity; †p<0.05 compared to control response in same group (ANOVA); #p<0.05 compared to response with VIP antagonist in same group (ANOVA); §p<0.05 compared to response with L-NNA in same group (ANOVA); ‡p<0.05 compared to young rats under same condition (t-test). All experiments were carried out under NANC conditions.