Table 1.
Electrophysiological measures of CSD, and systemic physiological parameters.
| CSD |
Systemic physiology |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | Age (mo) |
BW (g) |
Frequency (CSD/h) |
Speed (mm/min) |
Dur (sec) |
Amp (mV) |
BP (mmHg) |
pHa | paCO2 (mmHg) |
paO2 (mmHg) |
||
| WT | Naïve |
10 |
5±1 |
30±4 |
9±1 |
2.7±0.1 |
43±11 |
24±5 |
81±9 |
7.37±0.06 |
35±6 |
149±28 |
| Orx |
8 |
5±1 |
27±3 |
10±1 |
2.9±0.1 |
36±9 |
28±4 |
83±5 |
7.36±0.05 |
35±5 |
133±19 |
|
| Orx+TChronic |
4 |
4±0 |
27±1 |
9±1 |
2.8±0.2 |
41±7 |
23±1 |
86±1 |
7.40±0.03 |
31±3 |
142±18 |
|
| |
Aged |
5 |
11±0 |
37±3 |
9±1 |
2.7±0.0 |
23±9 |
24±4 |
87±5 |
7.43±0.02 |
31±3 |
157±19 |
| R192Q | Naïve |
19 |
5±1 |
27±3 |
12±1 |
3.8±0.2 |
37±10 |
23±5 |
84±5 |
7.38±0.05 |
32±6 |
133±22 |
| Orx |
16 |
5±1 |
27±2 |
17±2 |
4.1±0.1 |
32±8 |
25±7 |
86±5 |
7.37±0.05 |
32±4 |
140±20 |
|
| Orx+TChronic |
16 |
6±1 |
28±2 |
12±1 |
3.5±0.3 |
38±9 |
23±3 |
88±3 |
7.38±0.03 |
30±4 |
153±22 |
|
| Orx+TChronic+F25 |
7 |
8±0 |
30±6 |
12±0 |
3.7±0.2 |
32±6 |
18±2 |
85±7 |
7.42±0.04 |
33±5 |
161±18 |
|
| Orx+TChronic+F50 |
8 |
5±0 |
27±1 |
17±1 |
4.2±0.4 |
33±6 |
25±3 |
91±5 |
7.40±0.06 |
31±4 |
157±36 |
|
| Orx+TAcute |
6 |
7±0 |
28±2 |
16±2 |
4.3±0.3 |
33±10 |
25±4 |
90±5 |
7.40±0.03 |
31±3 |
151±37 |
|
| Aged | 7 | 13±2 | 37±4 | 12±1 | 3.6±0.3 | 42±12 | 27±3 | 80±6 | 7.37±0.05 | 34±5 | 146±19 | |
Values are mean ± standard deviation. CSD duration was measured at half amplitude.
The duration (Dur) and the amplitude (Amp) of only the first CSD are shown. Systemic physiological parameters were averaged over 1 hour recording duration.
BW: body weight; Orx: orchiectomized mice; TChronic: Testosterone 0.1 mg pellet for 21 days; TAcute: A single 1.2 mg dose of testosterone administered 1 hour prior to CSD testing; F25/50: Flutamide 25 or 50 mg/pellet for 21 days; BP: mean arterial blood pressure; pHa, paCO2, paO2: arterial blood gas values; WT, wild type; R192Q, homozygous R192Q knockin mice.