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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Mol Cell Neurosci. 2009 Sep 30;42(4):458–465. doi: 10.1016/j.mcn.2009.09.009

Figure 4. Aberrant proprioceptive projections in PTPRO-/- mice.

Figure 4

(A-D) P0 spinal cord sections stained with parvalbumin antibody to label proprioceptive projections in wt (A, C) and PTPRO-/- (B, D) mice. Arrowheads point to areas of aberrant axon projections. Disorganized and defasciculated axonal projections in PTPRO-/- mice are obvious in the magnified views (C, D). Additionally, the ratio of intermediate zone axonal projections to those in the ventral horn is higher in the PTPRO-/- mice. Both of these patterns were observed in all animals examined (n=7, wt; n=6, PTPRO-/-). (E, F) DiI labeled axon projections in P0 lumbar spinal cord. Fewer axons in PTPRO-/- mice reach their ventral horn motor neuron targets (arrowheads) compared to targets in the intermediate zone (arrows). Scale bars, 100μm.