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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Neuropharmacology. 2009 Jul 2;58(1):166–172. doi: 10.1016/j.neuropharm.2009.06.027

Figure 1.

Figure 1

Neuropathological changes in the rat retrosplenial cortex of rats. Systemic MK-801 administration induces vacuoles in pyramidal layer III-IV neurons of the retrosplenial cortex indicated by open arrowheads (A). These cytotoxic changes can be attenuated by pretreatment with NPS (B) or clozapine (C). (D) Schematic drawing of a coronal section of the rat brain at bregma −5.80. The red box indicates the location of areas that are shown in (A), (B) and (C), which are high power magnifications of layer III-IV of the retrosplenial cortex. Scale bar = 10 μm.