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. 2009 Nov 16;3:47. doi: 10.3389/neuro.08.047.2009

Figure 3.

Figure 3

Intrahippocampal METH sustains self administration. (A) Cumulative lever presses per day on the active and inactive levers during the 30-min test sessions across 7 days. Rats in the Ringer's (n = 11) and METH 10 μg/μl (n = 12) groups were co-treated with 250 μM SCH during days 5–7. METH 10 μg/μl group active lever presses were significantly greater than Ringer's group active lever presses from day 3 onward. METH group: upside-down black triangles; METH inactive: light gray diamonds; Ringer's: dark gray triangles. (B) METH induces lever-pressing in the hippocampus and not the cortex (CTX). All groups were co-treated with 100 μM SCH 23390 during days 5–7. Intrahippocampal METH group active lever presses were significantly greater than CTX METH and Ringer's vehicle groups from day 2 onward. The symbol * represents a difference from all other groups (P < 0.05). Hippocampus METH group: upside-down black triangles; Hippocampus METH inactive: light gray diamonds; Hippocampus Ringer's: dark gray triangles; CTX METH: black filled circles.