. Author manuscript; available in PMC: 2010 Jul 1.

Published in final edited form as: Am J Surg Pathol. 2009 Jul;33(7):984–991. doi: 10.1097/PAS.0b013e318198d666

Table 6.

Accuracy of C52 Antibody in Diagnosis of NMC

	% Sensitivity	% specificity	% PPV	% NPV
C52 IHC	87	100^a	100	99
FISH	93	100	100	~100
FISH + C52 IHC	100	100	100	100

Based on a total of 481 cases that were FISHd for NUT rearrangement.

Abbreviation: NMC, NUT midline carcinoma. IHC, Immunohistochemistry. FISH, Fluorescent in situ hybridization. PPV, Positive predictive value. NPV, Negative predictive value. TP, true positive. TN, true negative. FN, false negative. FP, false positive.

Sensitivity = TP/(TP + FN)

Specificity = TN/(FP + TN)

PPV = TP/(TP + FP)

NPV = TN/(TN + FN)