Figure 1.

Effect of PGE₂ or the combination of BMP-2 and PGE₂ on osteoclast formation in BM cultures. A) Cultures treated with PGE₂ (1 µM), or PGE₂ (1 µM) and BMP-2 (100 ng/ml). Osteoclasts per well were counted on the indicated days. B) Osteoclast numbers in cultures treated with increasing doses of PGE₂ alone or in combination with BMP-2 (100 ng/ml) for 5 days. Data are presented as mean ± SEM for 3 wells/group. ^aSignificantly different from PGE₂ alone, p<0.05.