Table 2.

Functional sorting of the genes within the four kinetically distinct groups observed in CVB4-V-infected BALB/c mice.

Functional Grouping	Gene Group
	1	2	3	4
TLR	tlr2, tlr3, tlr5	tlr4, tlr7, tlr9, myd88
Th17	csf2, ccl4, il6st, il17rb, tgfb1,tnfa, il22	cxcl2, il8ra, il17ra, il6ra, rorgt	csf3, cxcl1, il6, il8rb
Th1	ccl2, ccl3, ccr1, ccr3, cxcl10, ebi3, socs5	ccl5, ccr2, ccr5, cxcl9, cxcl11, cxcr3, ifng, ifngr1, nos2, tbet
Th2		gata3, tmed1
Treg				foxp3
Other		socs3		il13

Each functional group contains genes whose expression is associated with a specific response. For example, the TLR group contains genes encoding Toll-like receptors and adaptor molecules. Each of the remaining groups contains genes that are specific for a T cell subset (such as transcription factors, in italics) and genes that function in the activation and differentiation of specific T cell subsets and in the recruitment of effector cells (ex. neutrophils for Th17; macrophages and T cells for Th1).