. Author manuscript; available in PMC: 2010 Nov 1.

Published in final edited form as: J Autoimmun. 2009 Oct 12;33(3-4):239–246. doi: 10.1016/j.jaut.2009.09.004

Table 2.

Influence of Tregs and MHC class II expression on response to EAT induction with mTg or hTg.

Strain	Class II phenotype		Prior depletion of Tregs^a	EAT induction with mTg^b	EAT induction with hTg^b
	H2A/HLA-DQ	H2E/HLA-DR
B10	H2A^b	–	−	−	−
			+	+	−
E⁺B10	H2A^b	H2E^b	−	+	+
			+	++	++
E⁺B10.Ab⁰^c	–	H2E^b	−	−	++
			+	−	+++
DR3⁺Ab⁰^d	–	HLA-DR3	−	+++	+++
			+	+++	+++
DQ8⁺Ab⁰^d	HLA-DQ8	–	−	−	±
			+	±	+

Mice were injected i.v. with control IgG or CD25 mAb (PC61) to deplete CD25⁺ Tregs prior to immunization.

Mice were immunized with mTg or hTg and thyroiditis was assessed on day 28.

Deficient in A^b molecule due to knockout of Aβ chain.

Non-obese diabetic (NOD) background strain deficient in A^b molecule due to knockout of Aβ chain.