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. Author manuscript; available in PMC: 2010 Nov 3.
Published in final edited form as: Biochemistry. 2009 Nov 3;48(43):10416–10422. doi: 10.1021/bi901161b

Figure 4. Inhibition of VX hydrolysis by VR in H115W HuPON1.

Figure 4

A) Reaction velocity of VX hydrolysis versus concentration of VX (75 μM to 1.2 mM) in the presence of VR at 0 (▶), 29 (●), 60(▲), and 110 (▼) μM. B) Plot of 1/Vmax values derived from A) versus concentration of VR. The x-intercept of this graph corresponds to (−Ki), calculated to be 121 μM.