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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Biochim Biophys Acta. 2009 Aug 27;1791(12):1190–1196. doi: 10.1016/j.bbalip.2009.08.008

Figure 5.

Figure 5

DHA attenuates LXR-agonist induced activation of 1.5 kb SREBP-1c – Luc and of pLXREx3 - Luc. Hepatocytes were transfected with either (A.) 1.5 kb SREBP-1c – Luc or (B.) pLXREx3 - Luc and null renilla control. Following transfection, cells were incubated with or without T0901317 (5 μM) in the presence or absence of BSA (0.15%) or DHA (100 μM). After 24 hours of treatment, cells were lysed, luciferase activity measured and normalized to renilla luminescence. Data are expressed as the fold change in normalized luciferase from BSA + vehicle control and are the mean of at least four hepatocyte preparations (n ≥ 4). * P ≤ 0.05 vs. vehicle + BSA, # P ≤ 0.05 vs. T0901317 + BSA