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. Author manuscript; available in PMC: 2010 Nov 13.
Published in final edited form as: Prog Neuropsychopharmacol Biol Psychiatry. 2009 Jul 10;33(8):1291–1308. doi: 10.1016/j.pnpbp.2009.06.022

Figure 12.

Figure 12

This figure shows the effect of GSK876008 on pre- to post-shock changes in ‘baseline’ startle (i.e., on test trials without the 3.7-sec CS), which may be a conditioned response to the context CS. The shape of the dose-response curve was similar to that previously seen for light-enhanced startle in that intermediate doses of the CRF-R1 antagonist disrupted these increases.