Table 2.
Characterization of the Representative Compounds 6{R1,R2,R3} of Scheme 2
| Entry | Compound | Yielda | Purityb | MW(found)c |
|---|---|---|---|---|
| 1 | 6{1,1,5} | 76% | 90% | 982 |
| 2 | 6{1,2,5} | 76% | 90% | 1012 |
| 3 | 6{1,1,4} | 84% | 93% | 946 |
| 4 | 6{1,2,4} | 84% | 90% | 976 |
| 5 | 6{2,1,1} | 85% | 98% | 950 |
| 6 | 6{2,2,1} | 79% | 99% | 980 |
| 7 | 6{4,2,1} | 85% | 91% | 954 |
| 8 | 6{3,2,1} | 83% | 90% | 954 |
| 9 | 6{4,2,2} | 91% | 99% | 1044 |
| 10 | 6{3,2,3} | 96% | 95% | 1010 |
| 11 | 6{2,1,2} | 76% | 94% | 1040 |
| 12 | 6{2,2,3} | 94% | 94% | 1036 |
a
The yield (%) was calculated by the weight of the solid obtained after F-SPE.
b
The purity (%) was based on the integration area of HPLC peaks detected at 214 nm.
c
MW (found) was determined by HPLC/ESI MS. Compounds in lines 11 and 12 were not used in the Suzuki coupling reactions.