Table 3.
Characterization of the Representative Compounds 5{R1,R2,R3} of Scheme 3
| Entry | Compound | Yielda | Purityb | MW(found)c |
|---|---|---|---|---|
| 1 | 5{6,1,3} | 84% | 99% | 1043 |
| 2 | 5{5,2,3} | 95% | 99% | 1039 |
| 3 | 5{7,2,3} | 90% | 99% | 1057 |
| 4 | 5{5,1,1} | 78% | 97% | 952 |
| 5 | 5{7,1,1} | 91% | 99% | 970 |
| 6 | 5{5,2,1} | 95% | 98% | 982 |
| 7 | 5{6,2,1} | 98% | 97% | 1017 |
| 8 | 5{7,2,1} | 99% | 97% | 1000 |
| 9 | 5{5,1,2} | 84% | 99% | 1042 |
| 10 | 5{5,2,2} | 99% | 98% | 1072 |
| 11 | 5{6,2,2} | 96% | 96% | 1107 |
| 12 | 5{7,2,2} | 96% | 92% | 1090 |
| 13 | 5{5,1,3} | 77% | 96% | 1008 |
| 14 | 5{7,1,3} | 98% | 99% | 1027 |
| 15 | 5{6,2,3} | 92% | 89% | 1072 |
| 16 | 5{6,1,1} | 97% | 98% | 987 |
| 17 | 5{6,1,2} | 100% | 91% | 1077 |
| 18 | 5{7,1,2} | 96% | 96% | 1060 |
a
The yield (%) was calculated by the weight of the solid obtained after F-SPE.
b
The purity (%) was based on the integration area of HPLC peaks detected at 214 nm.
c
MW (found) was determined by HPLC/ESI MS. Compounds in lines 13–18 were not used in the nitro reductions/cyclizations.