Table 4.
Characterization of the Representative Compounds 6{R1,R2,R3} of Scheme 3
| Entry | Compound | Yielda | Purityb | MW(found)c |
|---|---|---|---|---|
| 1 | 6{6,1,3} | 83% | 69% | 980 |
| 2 | 6{5,2,3} | 91% | 89% | 976 |
| 3 | 6{7,2,3} | 89% | 83% | 994 |
| 4 | 6{5,1,1} | 76% | 92% | 890 |
| 5 | 6{7,1,1} | 91% | 82% | 908 |
| 6 | 6{5,2,1} | 84% | 67% | 920 |
| 7 | 6{6,2,1} | 53% | 67% | 954 |
| 8 | 6{7,2,1} | 66% | 68% | 938 |
| 9 | 6{5,1,2} | 74% | 28% | 980 |
| 10 | 6{5,2,2} | 86% | 98% | 1010 |
| 11 | 6{6,2,2} | 95% | 93% | 1044 |
| 12 | 6{7,2,2} | 93% | 62% | 1028 |
| 13 | 6{5,1,3} | 91% | 88% | 946 |
| 14 | 6{7,1,3} | 79% | 87% | 964 |
| 15 | 6{6,2,3} | 78% | 84% | 1010 |
| 16 | 6{6,1,1} | 84% | 82% | 924 |
| 17 | 6{6,1,2} | 86% | 92% | 1014 |
| 18 | 6{7,1,2} | 91% | 83% | 998 |
a
The yield (%) was calculated by the weight of the solid obtained after F-SPE.
b
The purity (%) was based on the integration area of HPLC peaks detected at 214 nm.
c
MW (found) was determined by HPLC/ESI MS. Compounds in lines 13–18 were not used in the Suzuki coupling reactions.