Table 5.
Characterization of the Representative Compounds 7{R1,R2,R3,R4} (Scheme 2)
| Entry | Compound | Yielda | Purityb | MW(found)c |
|---|---|---|---|---|
| 1 | 7{2,2,1,1} | 10% | >90% | 558 (MH+) |
| 2 | 7{4,2,1,1} | 26% | >90% | 532 (MH+) |
| 3 | 7{1,2,4,1} | 17% | >90% | 554 (MH+) |
| 4 | 7{3,2,1,1} | 21% | >90% | 532 (MH+) |
| 5 | 7{3,2,4,1} | 15% | 98% | 588 (MH+) |
| 6 | 7{1,1,4,5} | 10% | 87% | 514 (MH+) |
| 7 | 7{1,1,4,6} | 76% | 93% | 566 (MH+) |
| 8 | 7{2,1,1,7} | 36% | 100% | 584 (MH+) |
| 9 | 7{2,1,1,2} | 42% | 100% | 578 (MH+) |
| 10 | 7{2,2,1,3} | 53% | 97% | 602 (MH+) |
| 11 | 7{3,2,1,4} | 19% | 89% | 558 (MH+) |
| 12 | 7{4,2,1,5} | 17% | 90% | 522 (MH+) |
| 13 | 7{4,2,1,6} | 35% | 91% | 574 (MH+) |
| 14 | 7{4,2,2,2} | 23% | 98% | 672 (MH+) |
| 15 | 7{3,2,4,7} | 21% | 100% | 644 (MH+) |
| 16 | 7{1,1,5,6} | 49% | 99% | 602 (MH+) |
| 17 | 7{1,1,5,7} | 54% | 99% | 616 (MH+) |
| 18 | 7{1,2,5,3} | 15% | 86% | 634 (MH+) |
| 19 | 7{1,2,5,4} | 12% | 89% | 616 (MH+) |
| 20 | 7{4,2,2,8} | 0% | ||
| 21 | 7{1,2,4,8} | 0% |
a
The yield (%) was calculated by the weight of the solid obtained after F-SPE.
b
The purity (%) was an average of UVTWC and ELSD purities.
c
MW (found) was determined by HPLC/ESI MS. Compounds in lines 20 and 21 were not obtained.