Table I.
| Cytokine | Treatment (mean +/- SE) | |||
|---|---|---|---|---|
| Saline (n = 4) | Indo (n = 5) | LPS (n = 5) | Indo + LPS (n = 4) | |
| G-CSF | 44.7 +/- 12.7 | 5786 +/- 1171* | > 10,000 +/- 0 *# | > 10,000 +/- 0*# |
| GM-CSF | 17.1 +/- 17.1 | 57.9 +/- 20.8 | 699 +/- 358 | 194 +/-21.5 |
| IFN | 0 +/- 0 | 0.9 +/- 0.9 | 0 +/- 0 | 7.2 +/- 3.0 |
| IL-10 | 9.9 +/- 6.5 | 48.3 +/- 13.3 | 240 +/- 46.6*# | 331 +/- 49.6*# |
| IL-12p70 | 59.2 +/- 21.8 | 107 +/- 30.8 | 22.1 +/- 17.4 | 31.7 +/- 4.2 |
| IL-13 | 95.6 +/- 6.2 | 104.5 +/- 9.5 | 22 +/- 7.6*# | 19.3 +/- 1.5*# |
| IL-15 | 4.3 +/- 4.3 | 21.1 +/- 12.0 | 28.1 +/- 24.4 | 0 +/- 0 |
| IL-17 | 0 +/- 0 | 0.8 +/- 0.8 | 0.7 +/- 0.4 | 14.8 +/- 9.3 |
| IL-1α | 16.2 +/- 4.2 | 433 +/- 129* | 670 +/- 224* | 1036.1 +/- 26.2*# |
| IL-1β | 0.5 +/- 0.5 | 4.9 +/- 1.5 | 34.7 +/- 17.8 | 20.1 +/-10.8 |
| IL-2 | 3.5 +/- 2.4 | 7.4 +/- 1.5 | 3.6 +/- 1.1 | 4.5 +/- 1.1 |
| IL-4 | 0 +/- 0 | 0 +/- 0 | 0 +/- 0 | 0 +/- 0 |
| IL-5 | 17.5 +/- 13.8 | 155 +/- 94.4 | 77.0 +/- 7.0 | 260 +/- 115 |
| IL-6 | 1.3 +/- 0.5 | 1914 +/- 1106 | 9431 +/- 3264*# | 12630 +/- 360*# |
| IL-7 | 3.8 +/- 2.2 | 11.2 +/- 2.7 | 6.3 +/- 2.8 | 5.3 +/- 0.5 |
| IL-9 | 209 +/- 40.9 | 119 +/- 60.0 | 109 +/- 63.3 | 609 +/- 415 |
| IP-10 | 85.0 +/- 46.3 | 492 +/- 135 | 1325 +/- 390*# | 2236 +/- 145*#@ |
| KC | 2.0 +/- 1.2 | 978 +/- 479 | 5006 +/- 1679*# | 8268 +/- 1162*#@ |
| MCP-1 | 15.6 +/- 6.4 | 1163 +/- 664 | 8381 +/- 2926*# | 10300 +/- 1573*# |
| MIP1-α | 45.3 +/- 14.3 | 112 +/- 29.2 | 168 +/- 64.4 | 422 +/- 44.4*#@ |
| RANTES | 0 +/- 0 | 2.9 +/- 1.8 | 76.8 +/- 17.7*# | 117 +/- 13.5*#@ |
| TNF-α | 1.7 +/- 0.7 | 116 +/- 87.2 | 88.4 +/- 64.2 | 104 +/- 19.5 |
*
any group compared to saline;
#
LPS or Indo+LPS compared to Indo;
@
LPS compared to Indo+LPS; all comparisons at p<0.05. The p values are from the Newman-Keuls multiple comparison test following ANOVA.
Abbreviations: G-CSF, granulocyte colony-stimulating factor ; GM-CSF, granulocyte-macrophage colony-stimulating factor; IFN, interferon; IL, interleukin; IP, interferon gamma inducible protein ; KC, keratinocyte derived chemokine; MCP, macrophage chemotactic peptide; MIP, macrophage inflammatory protein; RANTES, regulated on activation, normal T cell-expressed, and secreted protein; and TNF, tumor necrosis factor alpha.